Search on: PYRUVATE DEHYDROGENASE COMPLEX 
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Descriptor English:   Pyruvate Dehydrogenase Complex 
Descriptor Spanish:   Complejo Piruvato Deshidrogenasa 
Descriptor Portuguese:   Complexo Piruvato Desidrogenase 
Synonyms English:   Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate  
Tree Number:   D05.500.562.625
D08.811.600.741
Definition English:   A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) 
Entry Combination - descr/qualif English:   Pyruvate Dehydrogenase Complex/deficiency use Pyruvate Dehydrogenase Complex Deficiency Disease
 
History Note English:   74(73) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   12205 
Unique Identifier:   D011768 

Occurrence in VHL: 		 

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